Waking up with sore legs in the morning can be caused by the following reasons: first, cold, when the calf is cold, can lead to chronic sterile inflammation of the muscles and fascia of the calf, and lead to the symptoms of soreness in the morning, when it is necessary to get out of the cold environment early, early physical therapy and warmth. Second, rheumatoid, when rheumatoid serious can involve the whole body of the bone and joint, but also the limbs of the muscles and soft tissues, the morning after the symptoms of calf pain, then the blood tests and X-ray of the bone and joint to diagnose. Third, ankylosing spondylitis, severe ankylosing spondylitis can involve the bones and joints of the whole body as well as muscles and soft tissues, resulting in symptoms of calf pain in the morning, which can be accompanied by morning stiffness and pain in the sacroiliac joints and lumbar spine, which should be diagnosed by examining x-rays of the sacroiliac joints and lumbar spine and blood tests.