Symptoms of palmoplantar pustulosis include aseptic blisters and pustules on the palms of the hands and soles of the feet, with erythema and desquamation when the pustules subside. Palmoplantar pustulosis is a chronic relapsing disease with an unknown etiology that may be related to localized infections, metal allergies, smoking, genetics, and stress. Symptoms of palmoplantar pustulosis include aseptic blisters and pustules on the palms of the hands or soles of the feet, which are often bilateral or unilateral in distribution. The pustules often merge with each other and resolve on their own, and when they do, there may be well-defined erythema, desquamation, and hyperkeratosis, or a brown blotchy rash. After suffering from palmoplantar pustulosis, it is recommended that the patient go to a regular hospital to consult a doctor and under the guidance of the physician for treatment.