A complete cure for palmoplantar pustulosis has not yet been developed, so palmoplantar pustulosis cannot be completely cured. However, it can be improved by topical medication, oral medication and physical therapy. 1. Topical medication: For patients suffering from palmoplantar pustulosis, it is recommended to follow the doctor’s instructions to use topical glucocorticoid medication, which is one of the most widely used therapeutic drugs for the treatment of the disease, with anti-inflammatory and immunosuppressive effects, and common medications such as halomethasone, hydrocortisone, and so on. 2. Oral drug therapy: for patients with extensive skin lesions, they need to take oral cyclosporine, methotrexate and other immunosuppressive drugs under the guidance of a doctor, which can reduce the body’s immune response, and help alleviate the patient’s local symptoms. 3. Physical therapy: patients with large lesions can also choose physical therapy, such as long-wave ultraviolet light, narrow-spectrum medium-wave ultraviolet light and excimer laser, which can improve the symptoms of palmoplantar pustulosis. Palmoplantar pustulosis usually cannot be completely cured, but there are many ways to improve the disease. Patients are advised to go to regular hospitals and cooperate with doctors for standardized treatment.