Palmoplantar pustulosis is a skin disease that manifests as recurrent pustules on the palms of the hands or soles of the feet, with a chronic course that does not heal on its own, and prompt medical attention and standardized treatment are recommended. Smoking, stress, infections and medications may contribute to the development and exacerbation of pustulosis palmoplantaris, and there is a genetic correlation between the development of pustulosis palmoplantaris. Pustulosis palmoplantaris is characterized by alternating worsening and partial remission, and is difficult to treat, with the main treatment being general and pharmacological. General treatment: patients with palmoplantar pustulosis should pay attention to skin moisturization, wear gloves to avoid irritation, avoid smoking or actively quit smoking. Medication: Topical corticosteroids such as triamcinolone and clobetasol cream, oral retinoids such as avitamin A and avitamin A ester. Immunosuppressive therapy with cyclosporine or methotrexate may be beneficial in improving the condition in some patients. Other treatments: photochemotherapy such as psoralens combined with ultraviolet A band (PUVA).