Palmar-plantar pustulosis is not contagious. It is a chronic, relapsing disease, often confined to the palmoplantar area, with periodic occurrence of small sterile pustules on top of an erythematous base, accompanied by keratinization and desquamation of the skin. The disease is chronic in course and responds poorly to some medications. The disease is usually more common in women than in men and is more common in women aged 50-60 years. The main site of onset of palmoplantar pustulosis is in the palmoplantar area, which usually appears as a gray-red plaque, often with flaking on the surface, and a smooth dark red surface after scale removal, and many numbers of small pustules within the plaque, fresh pustules are yellow, old pustules are yellow-brown or black-brown, and eventually the pustules will dry up and flake. In the treatment, the first thing is to remove the infected lesion, some think it is installed metal teeth, those who use mercury and silver filler should do metal plaque paste test, those who are positive should remove metal teeth and filler, also can consider the application of tetracycline, retinoic acid drugs for treatment, so palmoplantar impetigo belongs to a kind of sterile, pustular skin disease, not infectious.