If palmoplantar pustulosis is left untreated, it will cause the aggravation of the original symptoms, such as erythema, skin flaking, pustules, etc., and even cause complications such as nail abnormalities. 1. Erythema: this is a common symptom of palmoplantar pustulosis, which occurs on the palms of the hands or soles of the feet, and if the patient does not receive timely treatment, it may cause further aggravation of local erythema and even spread. 2. Skin flaking: palmoplantar pustulosis, if not treated, will cause local hyperkeratosis, and then the symptoms of skin flaking, accompanied by itching, seriously affecting daily life and work. 3. Pustules: usually distributed bilaterally, the pustules will be fused with each other, and recurring, sometimes mild, sometimes severe, never healed, when the patient’s hand and foot activities will be limited, and even can not walk normally. 4. Nail abnormality: this is a complication of palmoplantar pustulosis, the nails of patients with this disease will be involved, appearing punctate depression, transverse grooves, discoloration of the nail plate, turbid nail, nail peeling, pus accumulation under the nail and so on. Therefore, after the occurrence of palmoplantar pustulosis, patients should go to the hospital as soon as possible, so as not to delay the condition and affect the quality of life of patients.