Palmoplantar pustulosis is a chronic skin disease that occurs in the palmoplantar region and is prone to recurrence. Its treatment mainly includes local therapy, systemic therapy and physical therapy. 1. Local treatment: topical glucocorticosteroids such as trimethoprim, florazepam, betamethasone dipropionate, clobetasol propionate, etc.; retinoic acid cream; vitamin D3 cream such as tacalcitol, calcipotriol, etc.; salicylic acid ointment. 2. Systemic therapy: available retinoids such as avitamin A, isotretinoin and aromatic retinoic acid ethyl ester, etc.; immunosuppressants such as tretinoin, colchicine, cyclosporine A, etc.. 3. Physical therapy: ultraviolet light therapy. When palmoplantar pustulosis is diagnosed, it is recommended to consult a doctor in time for professional treatment under the doctor’s guidance.