Palmoplantar pustulosis does not affect the patient’s life expectancy, and the lesions only occur in the palmoplantar areas of the hands and feet, but it is still necessary to go to the hospital in time and actively treat it. Palmoplantar pustulosis refers to a skin disease that occurs in palm and metatarsal areas such as palms, feet, etc. and is characterized by erythema, scaling and pustules, often accompanied by intense itching. Palmoplantar pustulosis is generally not serious, and during its onset, progression, and healing, the skin damage is limited and does not affect the general state of health, nor does it have an impact on life expectancy. However, palmoplantar pustulosis has a long course and is prone to recurring episodes. Under the guidance of medical professionals, targeted treatment is needed according to the severity of the disease, the period of the disease, and preventive measures to improve the quality of life.