Palmoplantar pustulosis is a common, chronic and highly recurrent inflammatory skin disease with erythema, scaling and pustules on the palms and soles of the feet. Palmoplantar pustulosis patients will initially be found in the palm and metatarsal parts of the excessive with keratinization, skin flaking, gradually itching and burning sensation, and then the formation of blisters, which quickly evolved into pustules, and when the pustules crusted and turned into brown scales, scales off and then form new blisters and pustules, and so on and so forth, and in severe cases, it will lead to activity limitation, which affects the normal life. In addition. The patient’s palms and metatarsals may also appear symmetrical erythema, and then appear multiple small pustules, small pustules gradually expand and merge to form large pustules, to be crusted and flaky and then continue to appear new pustules. During the crusting and desquamation of the pustules, patients often experience itching and burning sensations, which can lead to bleeding and pain. There may be other symptoms of palmoplantar pustulosis, if there is any obvious discomfort, it is recommended to go to a specialized hospital immediately for examination and treatment under the guidance of a doctor.