Desmoplastic liposarcoma is a highly malignant tumor that often occurs in the retroperitoneum, but also in the extremities, trunk and scrotum, and spermatic cord, etc. The age of onset is usually between 20 and 92 years. The dedifferentiated liposarcoma can be seen at the beginning of the tumor or can occur after the recurrence of the tumor. The dedifferentiated component can be fibrosarcoma, undifferentiated sarcoma or in rare cases myogenic sarcoma, which has a poor tumor prognosis and is prone to recurrence and metastasis. The most important factors affecting tumor prognosis are tumor site and the ability to be surgically resected, rather than the extent of dedifferentiation and cellular anisotropy. Usually dedifferentiated liposarcoma is found in the deep limbs, retroperitoneum, and paratesticular area of middle-aged and elderly people. It usually has a long history of disease, with sudden and rapid recent growth, and a large, multinodular yellow mass with solid, gray-brown cut surface and non-fatty areas with necrosis in the naked eye. There is a diversity of microscopic manifestations, the most common being highly malignant malignant fibrous histiocytoma, undifferentiated sarcoma, or mucinous fibrous sarcoma. Desmoplastic liposarcoma is more malignant and is usually treated with a combination of radiotherapy or drugs after surgical excision and, if necessary, genetic testing to see if targeted drug therapy can be done, etc.