Usually, in the clinic, we always meet some patients who complain that the semen they usually ejaculate is like jelly, which looks uncomfortable, and they always have uncomfortable symptoms such as frequent urination, urgent urination and incomplete urination. After taking semen examination, it turns out that the semen is not liquefied. The following are some detailed explanations. 1. What is semen non-liquefaction? Under normal circumstances, male semen is liquefied when it is just ejaculated out of the body, and will solidify into jelly or clot in a short period of time. After 10 to 30 minutes, semen will gradually liquefy into a watery liquid. This process is the liquefaction of semen, which is a normal physiological phenomenon. If semen is still jelly-like after more than 30 minutes of discharge, it is a delayed liquefaction; if it does not liquefy after more than 60 minutes, it is a pathological condition called semen non-liquefaction. 2. What are the causes of semen non-liquefaction? Many studies have shown that the secretions of the prostate and seminal vesicles are involved in the process of coagulation and liquefaction of semen. The coagulation factors produced by the seminal vesicles cause the semen to coagulate, while the semen liquefaction factors such as proteolytic enzymes and lysozyme produced by the prostate cause the semen to liquefy. Once inflammation occurs in the seminal vesicles or prostate, the secretion of the above factors may be impaired, resulting in an increase in coagulation factors or a decrease in liquefaction factors, and an imbalance between coagulation and liquefaction factors, resulting in semen not liquefying. The causes of this imbalance may be closely related to prostatitis, seminal vesiculitis, pathogenic microbial infection of the reproductive tract, deficiency of trace elements such as magnesium and zinc, production of anti-sperm antibodies, varicocele and ageing, excessive emotional anxiety and depression, etc. 3.Does seminal fluid insolubility have any effect on fertility? Due to the lack of enzymes in semen that can promote sperm liquefaction, semen is in a coagulated state when ejected into the vagina, making sperm agglutination or braking, slowing down or inhibiting the normal movement of sperm so that they cannot pass through the cervix, preventing them from combining with eggs and leading to infertility, therefore, semen insolubility is one of the important causes of male infertility. 4. How to treat? Empirical treatments such as anti-inflammatory, antioxidant, vitamin and trace element supplementation are the main treatments, while if chronic prostatitis is confirmed, prostatitis can be treated together. In addition, you can try Chinese medicine treatment.