The common causes of semen non-liquefaction are insufficient fibrinolytic enzymes secreted by the prostate gland due to seminal vesiculitis and prostatitis; lack of trace elements (magnesium, zinc, etc.); congenital prostate deficiency, etc. It is generally believed that the secretions of the prostate and seminal vesicles are involved in the process of coagulation and liquefaction of semen. The coagulation factors produced by the seminal vesicles cause the semen to coagulate, while the prostate produces proteolytic enzymes, lyso-fibrinolytic enzymes and other semen liquefaction factors to liquefy the semen. Once inflammation occurs in the seminal vesicles or prostate, the secretion of the above factors may be impaired, resulting in an increase in coagulation factors or a decrease in liquefaction factors, resulting in semen non-liquefaction. Therefore, the key to the treatment of semen non-liquefaction lies in the eradication of seminal vesicle and prostate diseases. Most patients will also get better with semen non-liquefaction after prostate and seminal vesicle diseases are cured. Under normal circumstances, male semen is liquefied when it is just ejaculated out of the body, and within a short time, it will solidify into jelly or clot, and after about 10 – 30 minutes of time, semen will liquefy into watery liquid, this process is the liquefaction of semen, this phenomenon is a normal physiological phenomenon. If the semen is still jelly-like after 30 minutes, it is a pathological condition and is called non-liquefaction of semen. This process is very much in line with the requirements of human fertility. The liquefied state of semen at the beginning is very conducive to ejaculation, then it becomes jelly-like in order to allow the semen to stay in the female vagina without flowing out easily, and later it liquefies again in order to allow the sperm in the semen to move fully so that it can swim along the female reproductive tract towards the fallopian tube area to facilitate sperm-egg union and fertilization. If this is not a physiological process, it means that there is a problem with the semen. The reason why semen coagulates into a jelly state is due to the coagulation proteins secreted by the seminal vesicle glands. The protein hydrolase and fibrinolytic enzymes secreted by the prostate gland in semen can break down this coagulated protein and cause semen to liquefy. Therefore, semen is not liquefied because of increased coagulation protein or decreased protein hydrolase and fibrinolytic enzymes. When semen analysis is performed, if semen is not coagulated, it may be due to defective ejaculatory ducts or congenital lack of seminal vesicle glands. Semen that is not liquefied often interferes with the free movement of sperm. Non-liquefied semen is visible under the microscope as sperm agglutinated in clumps, unable to move or only slowly wriggling. The movement of sperm in this type of semen in the female reproductive tract is obviously impeded, and it is impossible for sperm to move up into the cervical canal, uterine cavity and fallopian tubes, where they cannot meet the egg and make fertilization impossible. The common causes of semen non-liquefaction From a clinical point of view, semen non-liquefaction is often the result of insufficient fibrinolytic enzymes secreted by the prostate gland due to vesiculitis and prostatitis, or lack of trace elements (magnesium, zinc, etc.), or congenital prostate deficiency, etc. We know that the secretions of the prostate and seminal vesicles are involved in the process of coagulation and liquefaction of semen. The coagulation factors produced by the seminal vesicles cause the semen to coagulate, while the semen liquefaction factors such as proteolytic enzymes and lyso-fibrinolytic enzymes produced by the prostate cause the semen to liquefy. Once inflammation occurs in the seminal vesicles or prostate, the secretion of the above factors may be impaired, resulting in an increase in coagulation factors or a decrease in liquefaction factors, resulting in semen non-liquefaction. Therefore, when men have semen that does not liquefy, doctors often tell patients to check the prostate gland and so on. Based on the pathological phenomenon of semen non-liquefaction, it is clear that the key to treating semen non-liquefaction is to treat seminal vesicle and prostate gland diseases. If there is an infection, the pathogens of the infection are also checked, such as Mycoplasma solium, Chlamydia trachomatis, Mycoplasma genitalium, etc. A drug sensitivity test is done at the same time when the above pathogens are found, and you will get the right treatment. After the liquefaction of semen is normal, the vitality of sperm will often return to normal, but some patients still have problems with the quality of sperm even though the liquefaction returns to normal, in which case they can be treated with sperm promotion capsules, which are more effective. Treatment (1) Thoroughly treat primary lesions such as prostatitis and seminal vesicle adenitis to restore their normal function. (2) Use saline containing 4% alpha amylase to rinse the vagina before sexual intercourse or inject 1 ml in the vagina after sexual intercourse. The enzyme can also be mixed with 50 mg of cocoa butter to make a 3 cm long plug and inserted into the vagina before intercourse. The discovery of this method was inspired by the observation that saliva has the ability to liquefy semen. α-amylase not only promotes the liquefaction of semen and affects glycogen-containing vaginal or cervical secretions, but also serves as a source of energy for sperm activity. Therefore, this method is widely used. (3) Adding normal human seminal plasma to semen to induce liquefaction. However, it is first necessary to make sure that this seminal plasma does not contain anti-sperm antibodies, is free of infection, and has been previously processed by high-speed centrifugation, removal of sediment and freeze-thawing 3 times. (4) The semen is ejected into a container with culture fluid and repeatedly pumped with a syringe with 18 or 19 gauge needles until the semen is thin, then centrifuged twice, washed, and finally the sperm is resuspended in a certain amount of culture fluid for artificial insemination. Three suggestions to stay away from semen non-liquefaction (1) Stay away from rays: Rays are a kind of radiation pollution, and his harm is not to be underestimated, because a large amount of exposure to radiation can cause chromosomal aberrations in sperm. (2) pay attention to the living room decoration: formaldehyde has a strong damaging effect on the genetic material in the cells, it is a volatile organic substance, all kinds of decorative materials contain to varying degrees. So in the selection of decorative panels, be sure to choose qualified, low formaldehyde content of the material. In addition, benzene (often contained in paints, coatings, adhesives) is also an important source of pollution. Be careful not to buy paints or adhesives that contain benzene. After the house is renovated, it is best to open the doors and windows for 1 summer, and then move in to live as appropriate. Granite contains a kind of radioactive substance – radon. Radon is one of the rare gas elements and is the product of metamorphosis of radioactive elements such as radium and thorium. Radon, which is metamorphosed from radium, is a colorless gas with a half-life of 3823 days. Long-term exposure to radon is harmful to health and can also kill sperm and cause infertility. (3) Drug pollution: Frequent use of sedative drugs, anti-tumor drugs, chemical drugs such as bacitracin, furan drugs and hormone drugs can cause sperm growth disorder, sperm chromosome damage and breakage.